Anti -HMGB1 Mouse mAb GB12103

Alternative names:

HMGB1,HMG1,HMG3,SBP-1,HMG-1

Product info:

HMGB1 mouse monoclonalProtein full nameHigh mobility group protein B1SynonymsHMGB1, HMG1, HMG3, SBP-1, HMG-1, high mobility group box 1ImmunogenKLH conjugated Synthetic peptidecorresponding to Mouse HMGB1IsotypeIgGPurityAffinity purificationSubcellular locationNucleus. Chromosome. Cytoplasm. Secreted. Cell membrane. Endosome.Uniprot IDP09429, P63158, P63159ApplicationsApplicationsSpeciesDilutionPositive TissueIHC, IFHuman1:200-1:1000lymphomaBackgroundLike the histones, HMGB1 is among the most important chromatin proteins. In the nucleus HMGB1 interacts withnucleosomes, transcription factors, and histones. This nuclear protein organizes the DNA and regulates transcription.After binding, HMGB1 bendsDNA, which facilitates the binding of other proteins. HMGB1 supports transcription of many genes in interactions with many transcription factors. It also interacts with nucleosomes to loosen packed DNA and remodel the chromatin. Contact with core histones changes the structure of nucleosomes.ImagesImmunohistochemistry analysis of paraffin-embedded human lymphoma using HMGB1 (GB12103) at dilution of 1: 1000StorageStorageStore at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.Storage BufferPBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.NOTE: 1.This product is intended for research only.2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.

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