Background:

Transthyretin(TTR) is a plasma transport protein for thyroxine and retinol, through the association with retinol-binding protein. It is a homotetrameric protein synthesized mainly in liver, choroid plexus, retinal pigment epithelium, and pancreas.Within the CNS, TTR is the only known protein synthesized solely by the choroid plexus. Mutant and wildtype TTR give rise to various forms of amyloid deposition(amyloidosis). Defects in TTR are the cause of amyloidosis transthyretin-related(AMYL-TTR),hyperthyroxinemia dystransthyretinemic euthyroidal(HTDE) and carpal tunnel syndrome type 1(CTS1). In addition, positive immunostaining for TTR has been reported as a sensitive diagnostic marker of choroid plexus tumors.(22103483)

Clonality:

monoclonal

Classification:

Primary antibody

Alternative names:

ATTR, HsT2651, PALB, Prealbumin, TBPA, transthyretin, TTR

Specificity:

Human

Host:

Mouse

Isotype:

IgG1

Immunogen:

transthyretin

Purification:

Protein A+G purification

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

16kd

Form:

liquid

Applications:

ELISA, WB, IHC

Recommended dilution:

WB: 1:500-1:5000; IHC: 1:20-1:200

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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