anti- KEAP1 antibody
Background:
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Clonality:
monoclonal
Classification:
Primary antibody
Alternative names:
INRF2, KIAA0132, KLHL19
Specificity:
Human, Rat
Host:
Mouse
Isotype:
IgG2a
Immunogen:
kelch-like ECH-associated protein 1
Purification:
Protein A+G purification
Purity:
≥95% as determined by SDS-PAGE
Calculated molecular weight:
55-70 kDa
Form:
liquid
Applications:
ELISA, IHC, WB
Recommended dilution:
Request info at info@sobekbio.com
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
More info:
Email: info@sobekbio.com
Orders:
Email: orders@sobekbio.com
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