Background:

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.

Clonality:

monoclonal

Classification:

Primary antibody

Alternative names:

Adult folate binding protein, FBP, Folate receptor 1, folate receptor 1(adult), Folate receptor alpha, Folate receptor, adult, FOLR, FOLR1, FR alpha

Specificity:

Human

Host:

Mouse

Isotype:

IgG1

Immunogen:

folate receptor 1

Purification:

Protein A+G purification

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

38 kDa

Form:

liquid

Applications:

ELISA, WB,IHC

Recommended dilution:

WB: 1:500-1:2000; IHC: 1:50-1:500

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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