Background:

Fas(CD95/APO-1) is a transmembrane glycoprotein belonging to the tumor necrosis factor(TNF) receptor superfamily. It can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex(DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The molecular mass of native Fas is 38 kDa, the high molecular weight form(40-55 kDa) of Fas is due to glycosylation.

Clonality:

monoclonal

Classification:

Primary antibody

Alternative names:

ALPS1A, APO 1, Apo 1 antigen, APT1, CD95, FAS, FAS1, FASLG receptor, FASTM, TNFRSF6

Specificity:

Human, Mouse

Host:

Mouse

Isotype:

IgG2a

Immunogen:

Fas(TNF receptor superfamily, member 6)

Purification:

Protein A+G purification

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

38-45 kDa

Form:

liquid

Applications:

ELISA, WB, FC,IHC

Recommended dilution:

WB: 1:1000-1:8000; IHC: 1:50-1:500

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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