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Background:
Under normal oxygen conditions, HIF1a is continuously produced and destroyed, in a process involving hydroxylation, interaction with von Hippel-Lindau (VHL) protein, polyubiquitylation and subsequent proteasomal degradation. Under hypoxic conditions, hydroxylation is impaired and HIF1a is stabilized. HIF1a localizes in cytoplasm in normoxia, but it can translocate into nuclear in response to hypoxia. The calculated molecular weight of HIF1a is 93 kDa, but the modified protein HIF1a is about 110-120kDa (PMID: 11698256, .PMID: 7539918).
Clonality:
monoclonal
Classification:
Primary antibody
Alternative names:
BHLHE78, MOP1, PASD8
Specificity:
Human
Host:
Mouse
Isotype:
IgG1
Immunogen:
hypoxia inducible factor 1, alpha subunit(basic helix-loop-helix transcription factor)
Purification:
protein A+G purified
Purity:
≥95% as determined by SDS-PAGE
Calculated molecular weight:
120 kDa
Form:
liquid
Applications:
ELISA, IF, WB
Recommended dilution:
WB: 1:1000-1:10000; IF: 1:50-1:200
Storage:
More info:
Email: info@sobekbio.com
Orders:
Email: orders@sobekbio.com