Background:

PARP1 (poly(ADP-ribose) polymerase 1) is a nuclear enzyme catalyzing the poly(ADP-ribosyl)ation of many key proteins in vivo. The normal function of PARP1 is the routine repair of DNA damage. Activated by DNA strand breaks, the PARP1 is cleaved into an 85 to 89-kDa COOH-terminal fragment and a 24-kDa NH2-terminal peptide by caspases during the apoptotic process. The appearance of PARP fragments is commonly considered as an important biomarker of apoptosis.

Clonality:

monoclonal

Classification:

Primary antibody

Alternative names:

ADPRT, ADPRT 1, ADPRT1, pADPRT 1, PARP, PARP 1, PARP1, poly (ADP ribose) polymerase 1, Poly [ADP ribose] polymerase 1, Poly[ADP ribose] synthase 1, PPOL

Specificity:

Human, Mouse, Rat

Host:

Mouse

Isotype:

IgG1

Immunogen:

poly (ADP-ribose) polymerase 1

Purification:

protein A+G purified

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

115 kDa, 89 kDa

Form:

liquid

Applications:

ELISA, WB, IHC, IF

Recommended dilution:

WB: 1:5000 - 1:30000; IHC: 1:100 - 1:1000; IF: 1:50 - 1:500

Storage:

0.01MPBS pH 7.4,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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