Background:

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Clonality:

monoclonal

Classification:

Primary antibody

Alternative names:

IL1 beta, Catabolin, IL 1, IL 1 beta, IL1 BETA, IL1B, IL1beta, IL1F2, IL-1β, Interleukin 1 beta, interleukin 1, beta

Specificity:

Human, Rat

Host:

Mouse

Isotype:

IgG1

Immunogen:

interleukin 1, beta

Purification:

Immunogen affinity purified

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

35kDa

Form:

liquid

Applications:

ELISA, IHC, WB

Recommended dilution:

WB: 1:1000-1:4000; IHC: 1:50-1:500

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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