Background:

Keratins are a large family of proteins that form the intermediate filament cytoskeleton of epithelial cells, which are classified into two major sequence types. Type I keratins are a group of acidic intermediate filament proteins, including K9–K23, and the hair keratins Ha1–Ha8. Type II keratins are the basic or neutral courterparts to the acidic type I keratins, including K1–K8, and the hair keratins, Hb1–Hb6. KRT18, also named as CYK18, PIG46 and K18, is the most commonly found members of the intermediate filament gene family. KRT18 is a type I keratin which is found primarily in non squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas but not in squamous cell carcinomas.

Clonality:

monoclonal

Classification:

Primary antibody

Alternative names:

CK 18, CYK18, Cytokeratin 18, K18, keratin 18, KRT18

Specificity:

Human

Host:

Mouse

Isotype:

IgG2a

Immunogen:

keratin 18

Purification:

Protein A+G purification

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

48 kDa

Form:

liquid

Applications:

ELISA, WB, FC, IF, IHC

Recommended dilution:

WB: 1:5000-1:50000; IHC: 1:600-1:2000; IF: 1:20-1:200

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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