Background:

Receptor for hyaluronic acid(HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases(MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T(iTreg) cell stability and suppressive function(By similarity).

Clonality:

monoclonal

Classification:

Primary antibody

Alternative names:

LHR, MDU2, MDU3, MIC4

Specificity:

Human

Host:

Mouse

Isotype:

IgG2a

Immunogen:

CD44 molecule(Indian blood group)

Purification:

Protein A+G purification

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

80-95 kDa

Form:

liquid

Applications:

ELISA, WB, IHC, IF, FC

Recommended dilution:

WB: 1：500-1：5000; IHC: 1：50-1：200; IF: 1：10-1：100

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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