Background:

BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction(PMID: 9108035). BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria(PMID: 21763611). The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis(PMID: 8183579).

Clonality:

polyclonal

Classification:

Primary antibody

Alternative names:

BCL2L4,Apoptosis regulator BAX, BAX

Specificity:

Human, Mouse, Rat, Rabbit, Sheep

Host:

Rabbit

Isotype:

IgG

Immunogen:

BCL2-associated X protein

Purification:

Immunogen affinity purified

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

21 kDa

Form:

liquid

Applications:

ELISA, WB, IHC, IP, FC, IF

Recommended dilution:

WB: 1:1000-1:10000; IP: 1:1000-1:10000; IHC: 1:20-1:200; IF: 1:10-1:100

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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