Background:

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.

Clonality:

polyclonal

Classification:

Primary antibody

Alternative names:

APE, APE1, APEX, APX, HAP1, REF1

Specificity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

APEX nuclease (multifunctional DNA repair enzyme) 1

Purification:

Immunogen affinity purified

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

39 kDa

Form:

liquid

Applications:

ELISA, WB, IP, IF

Recommended dilution:

WB: 1:500 - 1:2000; IF: 1:50 - 1:100; IP: 1:50 - 1:200

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

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