Alternative names:

TNFRSF10B;RAILR2;RAIL-R2;D262;R5;ILLER;RICK2;TNFR9;RICKB

Description:

Recombinant human TNFRSF10B protein with C-terminal mouse Fc tag

Background:

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.

Molecular characterization:

TNFRSF10B (Ile56-Glu186) mFc(Pro99-Lys330)

Molecular weight:

The protein has a predicted molecular mass of 40.5 kDa after removal of the signal peptide.

Tag:

C-Mouse Fc Tag

Expression host:

HEK293

Target:

TNFRSF10B

Purity:

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Formulation / Reconstitution:

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.

Storage:

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

More info:

Email info@sobekbio.com

Orders:

Email orders@sobekbio.com