Alternative names:

Host:

Human

Immunogen:

Reactivity:

293F

Description:

PBS,pH7.4

Specificity:

AA Asp 28 - Arg 80 (Accession # P56856-2)

Bio-MW:

Applications:

Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies

Application dilution:

Recombinant protein from a target gene encoding the extracellular domain loop 1 of Homo sapiens claudin 18 (CLDN18), transcript variant 2 (NM_001002026), with a hFC tag.

Purification & Purity:

The protein was purified from 293F and the purity is > 95% (by SDS-PAGE).

Storage & Stability:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Background:

Claudin-18(CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2. IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is under investigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG.

Note:

For research use only, not for use in diagnostic procedure.