Background:
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.
Specificity:
CES1 polyclonal antibody detects endogenous levels of CES1 protein.
Alternative names:
ACAT;
Acyl coenzyme A cholesterol acyltransferase;
Acyl-coenzyme A:cholesterol acyltransferase;
Brain carboxylesterase hBr1;
Carboxyesterase ES-3;
Carboxylesterase;
Carboxylesterase 1 (monocyte/macrophage serine esterase 1);
Carboxylesterase 1;
Carboxylesterase 1 deficiency, included;
Carboxylesterase 2, formerly;
CE 1;
CEH;
Ces-1;
Ces1;
CES2;
CESDD1;
Cholesterol ester hydrolase, neutral, macrophage-derived;
Cholesteryl ester hydrolase;
Cocaine carboxylesterase;
EC 3.1.1.1;
Egasyn;
ES-HTEL;
ES-x;
Es22;
EST1_HUMAN;
Esterase 22;
Esterase;
hCE 1;
HMSE;
HMSE1;
Liver carboxylesterase 1;
Liver carboxylesterase 3;
Methylumbelliferyl acetate deacetylase 1;
MGC117365;
MGC156521;
Monocyte carboxylesterase deficiency, included;
Monocyte esterase deficiency, included;
Monocyte/macrophage serine esterase;
PCE-1;
pI 5.5 esterase;
Proline-beta-naphthylamidase;
REH;
Retinyl ester hydrolase;
Serine esterase 1;
Ses-1;
SES1;
TGH;
Triacylglycerol hydrolase;
Species reactivity:
Human,Mouse
Host:
Rabbit
Ig type:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Immunogen:
Recombinant full length Human CES1.
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Molecular weight:
~63 kDa
Applications:
WB IHC
Usage:
WB 1:500 - 1:2000
IHC 1:50 - 1:200
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Precautions:
For research use only, not for use in diagnostic procedure.
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